Cleavage of human complement component C5 by cysteine proteinases from Porphyromonas (Bacteroides) gingivalis . Prior oxidation of C5 augments proteinase digestion of C5

Phylogeny of the C3/C4/C5 complement-component gene family indicates that C5 diverged first.

A phylogenetic analysis of DNA sequences from the C3/C4/C5 complement-component family of vertebrates supported the hypothesis that the C5 gene diverged first from the common ancestor of C3 and C4 and that C3 and C4 diverged later. The close relationship of C3 and C4 was further supported by the fact that a hagfish complement-component gene showed evidence of being more closely related to both ...

Role of complement component C5 in cerebral ischemia/reperfusion injury.

We evaluated the role of complement component C5 during the course of cerebral ischemic reperfusion injury in a rat model of middle cerebral artery occlusion (MCAO). Systemic C5 inhibition was achieved with an anti-C5 monoclonal antibody, which significantly prevented the deterioration of the motor functions by reducing cerebral lesion and edema. Our results show that activated C5 complement co...

Predicting Unilateral Postlaminectomy C5 Palsy by Measuring C5 Exit Foramen Area on Preoperative Computed Tomography

Background. Postoperative C5 motor palsy is known as a common complication not only after cervical laminectomy but also after anterior discectomy. There is no consensus to verify any of the proposed mechanisms of C5 palsy following posterior cervical decompression. The authors of this article have found that C5 palsy is more common among patients with smaller C5 root exit foramen area. The purp...

Plasmin as a complement C5 convertase

Both the complement and coagulation/fibrinolytic systems are essential components of the host defense system that evolved early in the evolution of vertebrates (Krem and Di Cera, 2002). While the coagulation and fibrinolytic systems are necessary for maintenance of the integrity of the vasculature, these systems also respond to infections, and together with the complement system, play an import...

Factors C3 and C5 Human Skin Mast Cells Express Complement